NK Cell Therapy: Cancer Treatment
What is Cancer
When cancer appears some of the body’s cells begin to divide without stopping and spread into surrounding tissues, generating abnormal cell growth. These extra cells can divide without stopping and may form growths called tumors.
Cancer can start almost anywhere in the human body, which is made up of trillions of cells. Normally, human cells grow and divide to form new cells as and when the body needs them. In the normal process when cells grow old or become damaged they die, and new cells take their place.
When cancer develops, however, this orderly process breaks down. As cells become more and more abnormal, old or damaged cells survive when they should die, and new cells form when they are not needed.
NK Cells Role in Cancer Treatment
Natural killer (NK) cells are lymphocytes that were first identified for their ability to kill tumor cells without deliberate immunization or activation. Subsequently, they were also found to be able to kill cells that are infected with certain viruses and to attack preferentially cells that lack expression of major histocompatibility complex (MHC) class I antigens.
Natural killer (NK) cells recognize targets stressed by malignant transformation or infection and can be long-lived. They become educated by interacting with major histocompatibility antigen (MHC) class I molecules to gain function to kill targets and produce cytokines.
As part of the innate immune system, natural killer cells don’t have to recognize a specific abnormality (antigen) on viral-infected cells or cancer cells. This is in contrast to some functions of immune cells which result from immunologic memory (the kind of functions for which immunizations are designed). If a cell is not recognized as being a normal part of the body, the NK cell can perform one of two functions.
+ NK cells may be cytotoxic (cell-killing): In this process, the NK cell penetrates the cell and releases toxic granules into the abnormal cells. These granules then create holes in the cell membrane, allowing them to swell and burst and killing the cell on contact. Instead of bursting, the cell may instead be directed in a process of controlled death called apoptosis.
+ Natural killer cells may also be used as a form of immunoregulation: In this process, the NK cells regulate the function of the immune system by producing substances known as cytokines. You can visualize cytokines as the “hormones of the immune system” which stimulate other parts of the immune system. It is these other parts of the immune system that, once stimulated, result in the death of the cancer cell or viral-infected cell.
NK Cell Therapy: CancerTreatment Protocol
All patients are advised to combine NK cell therapy with our Photodynamic Therapy (PDT) program for a targeted immunotherapy treatment. NK cells & PDT can be used as a stand-alone treatment, post surgery or in combination with matched chemo.
Our NK Cell Therapy Cancer Treatment is made up of either 2 or 6 infusions of activated NK cells. Each blood collection can produce 2 infusions of NK cells, meaning each patient will perform either 1 or 3 NK cultures to create their program.
Average expected outcome of each culture : 5,000,000,000 cells
Release structure of NK batches:
- 1st batch of NK cells to be released day 18 (average 2,000,000,000 cells)
- 2nd batch of NK cells to be released day 21 (average 3,000,000,000 cells)
NK Cell Therapy – Cancer Treatment Program Structure:
2 NK Cell Infusions Program:
6 NK Cell Infusions Program: